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Morning versus evening does not meaningfully change effectiveness for most patients

Avoiding alcohol, which causes vasodilation and can worsen hypotension, is advisable, particularly during the adjustment period

When to Contact Your Clinician: Red Flags and Persistent Pain Contact your doctor if aches last more than a few weeks, get worse, or come with: Fever Spreading redness Warmth at an injection site Marked swelling Sudden weakness Trouble breathing Also call if pain limits regular activity despite home care, or if you are considering regular use of pain medicines or supplements that might interact with other treatments

Hall, MD, MS, chair of the writing group for the Associations 2021 scientific statement on weight-loss strategies for prevention and treatment of hypertension and chair of the department of medicine at the University of Mississippi Medical Center