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We propose that these peptides may form a link between somatic cells and immune as well as neuroendocrine systems

However, more recent studies have demonstrated that the hepatic biosynthesis of AGT is the major source of renal ANG II concentrations and its renal expression depends on the integrity of the glomerular sieving function ( In fact, when the glomerular capillary wall, acting as a molecular barrier, is impaired, AGT protein is leaked into the tubular lumen and then reabsorbed at S1, S2 and S3 segments of proximal convoluted tubules ( The AGT reabsorption is a megalin-dependent process