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Commenters requested that, if use of the 2026 GMC is finalized, this value remain static until PE methodology is updated and does not get updated based on subsequent GMC changes

Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

No study examined tolerance or dependence with extended use, and no study followed a repeated-dosing cohort beyond a few months

Non-Antibiotic Periodontal Management AMPs represent a promising direction for managing periodontal disease without the collateral damage to the broader microbiome caused by systemic antibiotics