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Despite roughly five decades of work, no DSIP-specific binding site has been cloned, no DSIP gene has been isolated, and no signal-transduction pathway downstream of DSIP binding has been definitively characterized

Bibcode:2004PNAS..10110919F

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Fluctuations in the synthesis and metabolism of thyroid hormones targeting related microelements may result from microbial dysbiosis, leading to abnormal thyroid homeostasis ( The role of microbiota in iodothyronine metabolism It has been revealed that thyroid hormone homeostasis is closely related to the effect of gut microbiota on iodothyronine metabolism