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Dual incretin agonists achieve greater weight reduction than GLP-1RAs alone, and tirzepatide has now demonstrated cardiovascular safety noninferior to a proven GLP-1RA in patients with ASCVD as well as benefit in obesity-related HFpEF [40, 45]

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As AFib continues to affect more patients worldwide, clinicians need new strategies to reduce risk and improve long-term outcomes, presenting author Kenneth Bilchick, MD, professor of cardiovascular medicine at the University of Virginia, explained in a statement These findings suggest GLP-1-RAs may influence heart rhythm through mechanisms beyond weight loss