Keywords: allergy, cytokines, inflammation, mast cells, nitric oxide INTRODUCTION Nitric oxide (NO) plays diverse roles in biological systems: it is a mediator of vasodilatation, platelet aggregation and neurotransmission, and regulates function, death and survival of various cell types including many of those involved in immunity and inflammation [13]
In addition, the activation of melanocortin receptors in skin cells may also promote the synthesis and deposition of structural proteins such as collagen, which helps to enhance the strength and toughness of wounds
Navarro-Pern E, Cabezas-Herrera J, Campo LS, Rodrguez-Lpez JN
The findings were inconsistent in plasma where two studies reported higher activity in cases than controls [72, 81] and two reported lower activity [71, 83]