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The addressable obesity patient population conservatively estimated at 800 million people globally with BMI above 30, and considerably more when including the overweight population with comorbidities that justify pharmacotherapy dwarfs the T2DM market

The severity and duration of nausea vary considerably between individuals and between different GLP-1 preparations

GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent mannermeaning they only promote insulin release when blood glucose levels are elevated, which significantly reduces the risk of hypoglycaemia compared with some other diabetes medicines

Diabetes 48 , 22702276, doi:10.2337/diabetes.48.12.2270 (1999)