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Some patients using Tri-Luma Cream develop dark spots on their skin , tingling, increased skin sensitivity, rash, acne, skin redness caused by a condition called rosacea, skin bumps, blisters, or tiny red lines or blood vessels showing through the skin

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It has not yet been incorporated into Western clinical guidelines, but in China berberine is sometimes recommended as an adjunct for dyslipidemia or diabetes management, especially when statins or metformin are insufficient or not tolerated