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We have repeatedly stated, such as in the CY 2018 final rule, that we do not believe that very small numbers of voluntarily submitted invoices are likely to reflect typical resource costs and create the potential for overestimation of supply and equipment costs (82 FR 52998)

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Copper-Driven Tissue Irritation GHK-Cu binds to copper ions, which are essential for healingbut can also be irritating when introduced into tissue

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