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These high correlations are consistent with the hypothesis of a mechanistic link between antioxidant and glutamatergic systems in the human brain such that under steady-state conditions, low levels of glutathione are associated with low levels of glutamatergic neurotransmission [17]

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IGF-1 is a strong stimulator of sebaceous lipogenesis and acne pathogenesis has been linked to elevated IIS with consecutive nuclear FoxO deficiency [16, 17]

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