Although nicotinamide adenine dinucleotide (NAD+), a critical redox cofactor, declines in post-ovulatory oocytes, NR supplementation effectively prevents this loss, restoring metaphase II (MII) oocyte quality by maintaining chromosomal integrity and alleviating mitochondrial dysfunction, which may enhance ART success (Zhu et al., 2025)
So it is not known if using them causes side effects and how serious they are. Beyond the immediate risks, theres a concern about hormonal disruption, especially for people with underlying health conditions, hormone sensitivity, or those who are pregnant or breastfeeding
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