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Structural abnormalities of the BBB in CNS disease When multiple CNS diseases (such as Alzheimer's disease, multiple sclerosis, and stroke) occur, the resulting pathological responses (including inflammation, lipid peroxidation, and excitotoxicity) destabilize the BBB, leading to its dysfunction[38, 39]

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A secondary mechanism contributes to weight loss

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Adems, esta modificacin reduce la susceptibilidad a la enzima dipeptidil peptidasa-4 (DPP-4), que normalmente degrada rpidamente el GLP-1 natural

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