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You should ask your healthcare provider if any of the FDA-approved prescription medications, over-the-counter (OTC) drugs, vitamins, or supplements you take may interact with Rybelsus, including: Other diabetic medications such as insulin, sulfonylureas, and metformin Oral medications, since Rybelsus slows down gastric emptying (how fast your stomach empties) and can change how much of these meds are absorbed What are the possible side effects of Rybelsus