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It has been shown to inhibit apoptosis and cell death in primary cardiomyocyte and endothelial cell cultures (352), to have varying effects on the proliferation of various prostate carcinoma cell lines (353), to inhibit isoproterenol-induced lipolysis in rat adipocyte cultures (354), and to induce hypotension and bradycardia when injected into the nucleus tractus solitarii of rats (355)

Acknowledgements This study was supported by the NIDA Intramural Research Program