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A meta-analysis reported a weight loss of 4.19 kg (4.16%), a decrease in body mass index of 1.55 kg/m 2 , and a decrease in waist circumference of 3.11 cm when liraglutide was used [12]

While Dihexa-specific desensitization kinetics havent been comprehensively characterized, research on HGF and c-Met receptor signaling in other contexts indicates receptor downregulation begins within 24-48 hours of sustained agonist exposure, with maximum internalization occurring around 72 hours