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Many lawsuits allege that manufacturers knew or should have known about the risk of permanent gastroparesis and failed to include adequate warnings on the drug labels

doi: 10.1111/bph.15508 69

In addition, brain insulin resistance affects tau metabolism and promotes the hyperphosphorylation of tau proteins, tau protein aggregation, the formation of paired helical filaments, and the further formation of NFTs (Mohandas et al., 2009)