it can reduce H 2 O 2 in the presence of GPx by the reduction of its thiol group and keeps thiol groups from Hb, enzymes and membrane proteins in the reduced form [13], which is very important for the preservation of their functions, once oxidation of these groups can lead to functional and structural cellular modifications
Glutathione can eliminate free radicals in the body, thus preventing skin aging and pigment accumulation, giving the skin a radiant appearance
In summary, artesunate acts by reducing M1 macrophage activation and suppressing the RIPK1/RIPK3/MLKL signaling cascade through the downregulation of Mincle expression, thereby diminishing the inflammatory response and necroptosis, which contributes to improvement of renal injury in AKI
Sadeghi N, Mansoori A, Shayesteh A, Hashemi SJ (2020) The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis