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Petralla S, Saveleva L, Kanninen KM, Oster JS, Panayotova M, Fricker G, Puris E (2024) Increased expression of transferrin receptor 1 in the brain cortex of 5xFAD mouse model of Alzheimers disease is associated with activation of HIF-1 signaling pathway

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Cells were transfected using polyethyleneimine as described previously

They found that over this period, daily running distances increased initially for the group that underwent exercise training but then tapered off toward similar distances run before any training, which may have been due to muscle fatigue