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Clinical trials show berberine produces approximately 23 pounds of weight loss, while semaglutide (Ozempic's active ingredient) produces 3035 pounds over comparable timeframes

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The STEP trials (Semaglutide Treatment Effect in People with obesity) followed participants for 68 weeks of active treatment, showing sustained weight reduction without dose escalation

On an episode of the Huberman Lab podcast, neuroscientist Andrew Huberman, Ph.D., recommends avoiding berberine while intermittent fasting to prevent this effect