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Beyond that, desensitization is inevitable

Troglitazone Troglitazone was the first TZD approved for use in the United States and was licensed for use in T2DM in 1997, but withdrawn 3 years later because of the frequency of liver injury, including acute liver failure, associated with its use

J Coord Chem 70(8):14061423 Abdolmaleki S, Panjehpour A, Khaksar S, Ghadermazi M, Rostamnia S (2023) Evaluation of central-metal effect on anticancer activity and mechanism of action of isostructural Cu (II) and Ni (II) complexes containing pyridine-2, 6-dicarboxylate

Crucially, clinical analyses have shown that MCP acts as a selective chelator