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( Activin A, a member of the TGF- superfamily was thought to be involved in the pathogenesis of UF by increasing the ECM components, such as versican, fibronectin, and collagen 1A1, at least in part through activating the Smad-2/3 and p38-MAPK signaling pathway ( Alba cultivar of the strawberry extract was found to inhibit the induction of collagen 1A1, fibronectin, and versican mRNA expression by activin A in leiomyoma cells (

2 Interstitial fluid pressure The hydrostatic and osmotic pressure differences between the vasculature and the surrounding tissue move fluid out from the blood vessels to the interstitium, allowing the supply of nutrients and oxygen to the resident tissue cells [11]

Sikiric et al., 2012