Why Researchers Think This Matters Researchers believe these findings matter because semaglutide may influence brain pathways tied to reward, craving, mood, and stress response, not just appetite and metabolism
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"Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial." EClinicalMedicine 57 (2023)
Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses
