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Inositol also requires adequate water intake for proper cellular function

When assessing baseline characteristics by comparator (Additional file 4: Appendix Table S4C), the proportion of subjects with heart failure, other prior CV events and prior insulin use was higher, and mean eGFR was lower, in the placebo and semaglutide groups than in the other comparator groups, driven by the large patient numbers and high baseline CV risk in the CVOTs

One RCT found that exenatide significantly reduced drinking in individuals with AUD and obesity, but not in those without metabolic comorbidities (Klausen MK et al, JCI Insight 2022;7(19):e159863)

These are literally packed into fat cells