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While this pathway also impairs mitophagy, it does so to an extent that pushes the cell past a survival threshold, ultimately inducing caspase-9-dependent apoptosis and loss of migratory capacity in EESCs

Despite its pleiotropic mechanisms, resveratrols clinical translation has been hindered by pharmacokinetic limitations, such as rapid hepatic metabolism, poor aqueous solubility, and low bioavailability, which collectively undermine its therapeutic efficacy [3]

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