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Although IGF-1R lacks a nuclear localization sequence, experiments revealed that SUMOylation events as well as the receptors kinase activity are responsible for nuclear translocation

Ferroptosis is driven by dysregulation in three core metabolic pathways: thiol metabolism, lipid peroxidation, and iron metabolism ( It is increasingly recognized that ferroptosis, a regulated form of cell death, plays a critical role in diabetes and its complications, with its underlying mechanisms being continuously uncovered by recent studies