We found that GPx3 remains one of the most important proteins to discriminate children living with konzo from those not affected, using this supervised model for group clustering, regardless of disease stage severity (Fig
The timeline varies by individual based on baseline NAD+ depletion, methylation status, inflammatory load, and overall metabolic health
Validation of the glutathione pathway in tissue regeneration PCR quantified the transcriptional activity of glutathione pathway enzymesGCLC, GPXs, GSR, and GSTsat various postoperative intervals (1 day, 1 week, 1, 2, and 6 months), with a significant peak at one month, indicating a robust enzymatic response during tissue remodeling (Fig
The 100 nmol/kg dose of GEP44 was tested for one day only