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After just 6 h of ML226 treatment in HeLa cells, we were able to detect changes in lipoylation on ketoacid dehydrogenases, using an antibody that only detects the active, unmodified form of lipoate 16

From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization

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USP7 has been reported to affect the stability of HO-1 by regulating the ubiquitination of HO-1