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Studies have demonstrated that GLP-1s reduce major adverse cardiovascular events and slow progression of kidney disease, transforming these agents from glucose-lowering drugs into cardiorenal-metabolic disease modifiers with expanded addressable populations [1]

The PI3K/Akt/FOXO1 pathway might be involved in the regulation of Th17/Treg balance by exenatide, while FOXO1 inhibitors could block the regulatory effect of exenatide on Th17/Treg balance

Antihistamines to use with caution or avoid: Hydroxyzine and mizolastine should be avoided where possible in patients taking escitalopram due to the combined QT prolongation risk

Postgraduate Medicine, 134 (1), 1419