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Dendritic cells adopt a tolerogenic phenotype, expressing IDO1 and PD-L1 and producing IL10 and TGF-, which promotes regulatory T cell differentiation and suppresses effector T cell responses [333,334,335]

sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial