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The very low rate constants for direct, glutathione-independent dithiol-disulfide exchange reactions between glutaredoxins and roGFP2 or other protein(S 2 )/protein(SH) 2 couples (despite favorable thermodynamics) are a prerequisite and great advantage for reliable redox measurements in vivo

Though the disproportionality analysis and Bayesian analysis as a rapid and effective method for signal detection, our study represents the largest post-marketing surveillance to date of these GLP-1 RAs

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