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However, the effect is mild, and scientists are still studying how fasting affects GLP-1 15

FIGURE 3 Visceral fat is not only a storage depot but also acts as an endocrine organ, releasing a variety of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) (64)

Weight loss may theoretically alter thermoregulation as body composition changes, potentially affecting sweating patterns

Body weight loss had an estimated 0.5% mediation effect on the primary kidney outcome, a 33.4% mediation effect on CV events and a 25.6% mediation effect on all-cause death