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Efpeglenatide is a drug in which an exendin-4 analog is linked to a human immunoglobulin G4 fragment through a polyethylene glycol (PEG linker), allowing for Fc receptor of neonate (FcRn)-mediated recycling and reduced excretion through the kidneys [50]

Supporting this hypothesis, a chronic unpredictable mild stress mouse model demonstrated that melatonin effectively restored aquaporin-4 polarization and rectified the compromised glymphatic system observed in this model [215]

Improving Insulin Sensitivity In addition to managing hunger, semaglutide also helps regulate blood sugar by enhancing insulin sensitivity