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The yield stage includes both redox and phosphorylation reactions, leading to formation of four molecules of ATP during the conversion of the two triose phosphates into lactate
Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors
10.3389/fphar.2022.808855 160 ZhongZ.DUJ.ZhuX.GuanL.HuY.ZhangP.et al (2024)
Glutathione travels through the body, neutralising these free radicals and preventing them from causing harm
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