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Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)

Nasal Peptide Delivery The nasal mucosa provides direct vascular access to systemic circulation, bypassing hepatic first-pass metabolism

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HGF heptocyte growth factor MSP macrophage stimulating protein the AnglV analog Norleual which is a potent inhibitor of the HGF/Met system, was shown to bind to HGF and block its dimerization (Kawas et al, 2011)