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Use of this phrase has caused confusion, and its use should be avoided

Mechanistically, cofactor-dependent metabolic nodes illustrate how relatively small reductions in catalytic support can propagate across interconnected pathways involving nucleotide metabolism, redox homeostasis, and immunemetabolic regulation under conditions of metabolic stress [122,123,124,125]

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In 1973, when Greene sold the ranch, the ROs, as it came to be called, was the last of Greene Cattles working ranches, and its sale dissolved the storied organization