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Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study

Fernstrom, J

The gut microbiome is so complex and diverse that any imbalances within this bustling colony can not only impact the way we digest and assimilate nutrients from the food we eat but it can also disrupt the function of our hormones and neurotransmitters