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Topiramate can harm your unborn baby

This regimen (shown as a 50:50 dosage ratio) is more difficult to adjust because NPH has both a 2 hour delay, limited duration of action, and a time course that gives it prandial-like properties that can result in different levels of insulin stacking when another prandial insulin is given concomitantly (see Figure 14)

Nevertheless, no significant change was found in the subscale of social interaction