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Food aversion can develop when every meal feels like a chore

This scenario highlights the tension between ensuring drug availability and maintaining rigorous safety standards

Factors that should alert clinicians to possible nondiabetic aetiologies include an absence of retinopathy, duration of diabetes less than five years, acute renal injury pattern of renal dysfunction rather than gradual progression, presence of haematuria or other systemic disease and presence of nephrotic syndrome (albuminuria greater than 3 g/day, low serum albumin level, oedema and symptoms such as frothy urine)

Patients with a history of pancreatitis or significant gastrointestinal issues should be particularly cautious, as incretin-based therapies like Tirzepatide may exacerbate these conditions