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The tumor targeting ability of drug-disulfide-fluorophore conjugate could be enhanced by attaching a specific site-targeting ligands such as biotin, folate, galactose and RGD peptide which exhibit higher selectivity towards cancer cells over noncancer cells due to their genetic signatures or owing to overexpression of a particular receptors on certain cancer cells

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The decision comes despite the gene therapy missing the primary endpoint in its Phase III confirmatory study