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Figure 5 Biosynthesis of D-Allulose Using RhaD Aldolase With D-Glyceraldehyde as the Acceptor A main disadvantage of DHAP-dependent aldolase strategies is that the donor substrate DHAP is very expensive and unstable for large-scale synthesis (Schmperli et al., 2007)

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The FDA has approved these agents for type 2 diabetes management (not type 1 diabetes or diabetic ketoacidosis), with select formulations also approved for chronic weight management in adults with obesity or overweight with weight-related comorbidities

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