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The following used antibodies provided by Thermo Fisher Scientific, MA, USA were anti--actin (Cat# MA5-15739), anti-PKA (Cat# PA5-17626), and anti-p-CREB (Ser133) (Cat# PA1-4619)

We thank our Data and Safety Monitoring Committee, our TSC and Trial Management Group members, and our patient and public involvement and engagement representatives who reviewed the trial protocol and participated in our TSC and Monitoring Committees