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M., Bouton, C

This approval follows data from the STEP UP trial, which indicated that the gher dose led to a significant weight loss of 18.7% compared to 3.9% for placebo, with some participants achieving over 25% weight loss

Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine

Recent studies have demonstrated that metabolites derived from gut microbiota, particularly SCFAs, along with endogenous hepatic metabolites, can precisely modulate the transcription and expression of core clock genes