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Because T is derived from rate constants and does not have a physiologic basis, it is influenced by the sensitivity of the analytical method and by many pharmacokinetic parameters, and it is a poor parameter alone to evaluate physiologic (e.g., age, sex) or pathologic (e.g., renal failure) changes that effect drug disposition

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Bom custo-benefcio Apresentao em tabletes prticos 120 unidades por embalagem Marca estabelecida no mercado Dosagem fixa por tablete pode exigir mais unidades para doses altas Textura dos tabletes pode no agradar a todos 5

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