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Being overweight or obese is a major cause of disability and correlated with various diseases and conditions, particularly heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis

Weight loss was also significantly greater with tirzepatide: 7.6 kg to 11.2 kg versus 5.7 kg with semaglutide

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When AT-7687 was previously given alongside the GLP-1 agonist liraglutide, it had the best results in weight reduction and a major improvement in weight loss factors such as glycemic control and LDL-cholesterol levels were observed