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(141) further confirmed in 2023 that the H 2 S donor GYY4137 improves renal oxidative damage in diabetic mice by decreasing NADPH oxidase 2 (NOX2) expression and increasing heme oxygenase-2 (HO-2) and paraoxonase 1/2 (PON1/2) expression

Almost 90% of cellular GSH resides in the cytosol, with roughly 10% found in the mitochondria and a small fraction in the endoplasmic reticulum

This study is among the few that put forward the concept of metabolic flexibility in overweight and obese adolescents and in relation to anemia through an increased antioxidant status as measured by the redox status and GPx activity