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5 Division of Hospital Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA Correspondence: Rakesh Kumar, Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA, 55905, Email [email protected] Abstract: Acetyl-l-carnitine (ALC) is increasingly recognized for its potential psychopharmacological mechanism and role in the treatment of mood disorders, particularly major depressive disorder (MDD) and bipolar disorder (BD)