We applied 5% annual discounting for health economic outcomes
European neurology
Clues to RA: Small joints typically affected first Wrists Hands and feet joints More than one joint affected Same joints on both sides of your body Morning stiffness lasting more than 30 minutes Joint pain, tenderness, swelling, or stiffness for six weeks or longer Health effects of RA [Arthritis Foundation] Eyes: Dryness, pain, inflammation, redness, sensitivity to light, and trouble seeing properly Mouth: Dryness and gum inflammation, irritation, or infection Skin: Rheumatoid nodules or small lumps under the skin over bony areas Lungs: Inflammation and scarring that can lead to shortness of breath and lung disease Blood vessels: Inflammation of blood vessels that can lead to damage in the nerves, skin, and other organs Blood: A lower than normal number of red blood cells Heart: Inflammation can damage the heart muscle and the surrounding areas
The article says escalation should be paused or reversed if severe nausea, vomiting, acute abdominal pain, or signs of pancreatitis develop, and that any such change happens only under qualified provider supervision
