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Developed in the 1980s at the University of Arizona, this peptide was originally designed to stimulate melanogenesis for skin pigmentation but was subsequently found to produce significant effects on sexual function, appetite regulation, and social behavior

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BRAF-mutant melanoma with resistance to targeted therapies is characterized by increased reliance on OXPHOS, glutamine metabolism, and serine metabolism, which is partially driven by PGC1 [50,51,52,53]