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Based on the function of ACTL6A on GCLC regulating, we believe that the expression of ACTL6A plays an important role in it

Under normal conditions, Nrf2 is degraded through its interaction with Kelch-like ECH-associated protein 1 (Keap1), whereas under oxidative stress conditions, Keap1 is oxidized and Nrf2 is translocated to the nucleus, where it induces the expression of several genes 19

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The concern regarding an early increase in risk was most prominently highlighted by the SUSTAIN-6 trial, which found that patients undergoing semaglutide treatment exhibited an elevated risk of diabetic retinopathy complications [82]