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As you enter the second week, this is a great time to do the hard stuff- to keep at a task that has lost some of its shine, to push through some resistance, and to push your limits to see whats possible

The accumulation of AGEs in the epidermis can impair the function of the skin barrier and obstruct wound healing by increasing the production of matrix metalloproteinase MMP-9

2024 Jan 1;140(1):17880

A recent study revealed that with increasing age, oocyte senescence leads to the downregulation of all the cellular pathways involved in NAD+ synthesis (kynurenine pathway, Preiss-Handler pathway, and NAD+ rescue pathway) and profoundly affects the activity of NAD+-dependent enzymes, i.e., PARPs and SIRTs, with further implications for many cellular functions, including impaired ROS detoxification [83]